5/26/2023 0 Comments Pes2011 bal studio 1.0MAPK1 is an inhibitory regulator of HTR2A and facilitatory regulator for DRD1. The mitogen-activated protein kinase 1 (MAPK1) gene was significantly downregulated. A pathway analysis was performed that targeted serotonin and dopamine receptor pathways. A significant upregulation of the serotonin HTR2A receptor and significant downregulation of the dopamine DRD1 receptor genes were found. Following the occlusion protocol, 588 genes were found to be altered ( P < 0.05 log 2 fold change ≥ 0.4), with 327 genes downregulated and 261 genes upregulated. Obstructions were repeated for 10 min followed by immediate dissection of the medial thalamus. The cuff was inflated to obstruct 2–4 breaths, then deflated for a minimum of 15 breaths. Anesthetized rats were instrumented with an inflatable cuff sutured around the trachea. It was reasoned that if the thalamus is the neural gate, then tracheal obstructions will modulate the gene expression profile of the thalamus. The thalamus could be responsible for the gating of respiratory sensory information to the cortex. Conscious awareness of breathing requires the activation of higher brain centers and is believed to be a neural gated process.
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